2008: Ricercatore, Cattedra di Farmacologia, Università degli Studi di Roma Tor Vergata.
1999 – 2008: Funzionario Tecnico (prima VII qualifica funzionale, quindi qualifica funzionale VIII, livello D2 e D3) cattedra di Farmacologia, Facoltà di Medicina e Chirurgia, Università degli Studi di Roma Tor Vergata.
1995 – 1997: Borsa AIRC, Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Roma Tor Vergata.
1991 – 1994: Dottorato di Ricerca in Ematologia, Università degli Studi di Roma Tor Vergata.
1990: Laurea in Scienze Biologiche, Sapienza – Università di Roma; tesi: Controllo immunofarmacologico in vitro dell'infezione con HTLV-I: effetto degli interferoni ricombinanti a e b.
HIV-Tat down-regulates telomerase activity in the nucleus of human CD4 cells, Franzese O, Comandini A, Adamo R, et Al., Cell Death Differ / NPG, 2004, 18(4):197-201.
Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection, Franzese O, Kennedy PT, Gehring AJ, et Al., J Virology, 2005, 79(6):3322-8.
Telomerase activity, hTERT expression and phosphorylation are down-regulated in CD4+ T lymphocytes infected with Human Immunodeficiency Virus Type 1 (HIV-1), Franzese O, Adamo R, Pollicita M et Al., J. Med. Virology, 2007, 79 (5):639-646.
The regulation of telomerase activity by co-stimulation during progressive differentiation of memory CD8+ T cells, Plunkett FJ, Franzese O et Al., J. Immunology, 2007, 178 (12):7710-7719.
KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cellS, Henson SM, Franzese O et Al., Blood, 2009, 113 (26): 6619-6628.
Interfacing Sca-1pos mesenchymal stem cells with biocompatible scaffolds with different chemical composition and geometry, Forte G, Franzese O et Al., J Biomed Biotechnol, 2009, Article ID 910610, 10 pages. doi:10.1155/2009/910610.
Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes, Comandini A, Naro C, Adamo R, Akbar AN, Lanna A, Bonmassar E, Franzese O, Molecular immunology, 2012, 31;54(2):181-192. doi: 10.1016/j.molimm.2012.12.003.
IFN-α inhibits telomerase in human CD8+ T cells by both hTERT downregulation and induction of p38 MAPK signaling, Lanna A, Coutavas E, Levati L, Seidel J, Rustin MH, Henson SM, Akbar AN, Franzese O, J. Immunology, 2013, 191:3744-52. doi: 10.4049/jimmunol.1301409.
Defect in HSP90 expression in highly differentiated CD8+ T cells, Franzese O, Henson SM, Naro C, Bonmassar E, Cell Death Disease, 2014, 12;5:e1294. doi: 10.1038/cddis.2014.259.
p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+T cells, Henson SM, Lanna A, Riddell NE, Franzese O et Al., Journal Clinical Investigation, 2014 , 124:4004-16. doi: 10.1172/JCI7505.