Daniela Palacios | Fondazione Santa Lucia
Attività di Ricerca 

Epigenetica. Trasduzione del Segnale. Rigenerazione muscolare. Cellule staminali muscolari. Rhabdomyosarcoma.

Biografia 

2014: Editor, Frontiers in Cell and Developmental Biology.

2012: Academic Editor, ISRN Genetics.

2012: Guest Editor, Comparative and Functional Genomics (Lancio di una pubblicazione speciale: “Epigenetic control of reprogramming and cellular differentiation”).

2012: Ricercatore-Team Leader, Fondazione Santa Lucia IRCCS, Roma.

2005 – 2011: Post-doc Dulbecco Telethon Institute e Fondazione Santa Lucia IRCCS, Roma.

2007: Ricercatore ospite, Sanford-Burnham Institute for Medical Research, La Jolla, (USA).

2000 – 2004: Dottorato di Ricerca in Biochimica, Institute of Cancer Research, London (Regno Unito) e Universidad Autonoma de Madrid.

1994: Laurea in Biochimica e Biologia Molecolare, Universidad Autonoma de Madrid.

Chromatin signalling in muscle stem cells: interpreting the regenerative microenvironment, Brancaccio A, Palacios D, Frontiers in Aging Neurosciences, 2015.

Depletion of Polycomb group (PcG) protein EZH2 induces apoptosis of alveolar rhabdomyosarcoma by up-regulating FBXO32 (Atrogin1/MAFbx), Ciarapica R, De Salvo M, Carcarino E, Bracaglia G, Adesso L, Leoncini PP, Dall’Agnese A, Walters Z, Verginelli F, De Sio L, Boldrini R, Inserra A, Bisogno G, Rosolen A, Alaggio R, Ferrari A, Collini P, Locatelli M, Stifani S,  Screpanti I, Rutella S, Yu Q, Marquez VE, Shipley J, Valente S, Mai A, Miele L, Puri PL, Locatelli F, Palacios D, Rota R, Oncogene,  2014,  pgg.

Phosphoryl-EZH-ion, Caretti G, Palacios D, Sartorelli V, Puri PL,  Cell Stem Cell,  2011,  262-5.

Selective control of Pax7 expression by TNF-activated p38a/polycomb repressive complex 2 (PRC2) signalling during muscle satellite cell differentiation, Mozzetta C, Consalv Si, Saccone V, Puri PL, Palacios D, Cell Cycle,  2011, 191-8.

TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration, Palacios D, Mozzetta C, Consalvi S, Caretti G, Saccone V, Proserpio V, Marquez VE, Valente S, Mai A, Forcales SV, Sartorelli V, Puri PL, Cell Stem Cell. 2010 Oct 8;7(4):455-69. doi: 10.1016/j.stem.2010.08.013.

Interplay between DNA methylation and transcription factors availability: Implications for developmental activation of promoters with an intermediate C-G density, Palacios D, Summerbell D, Rigby PJW, Boyes J,  Molecular and Cellular Biology,  2010,  3805-3815.

Switch NFix developmental myogenesis, Palacios D, Puri PL,  Developmental Cell,  2010,  340-1. 

Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation, Serra C, Palacios D, Mozzetta C, Forcales SV, Morantte I, Ripani M, Jones DR, Du K, Jhala US, Simone C, Puri PL, Mol Cell. 2007 Oct 26;28(2):200-13.

Epigenetic control of adult stem cell differentiation: the paradigm of muscle regeneration, Palacios D, PL Puri PL,   Journal of Cellular Physiology,  2005, 1-11.

Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS, Ciarapica R, Carcarino E, Adesso L, De Salvo M, Bracaglia G, Leoncini PP, Dall'agnese A, Verginelli F, Milano GM, Boldrini R, Inserra A, Stifani S, Screpanti I, Marquez VE, Valente S, Mai A, Puri PL, Locatelli F, Palacios D, Rota R, BMC Cancer. 2014 Feb 27;14:139. doi: 10.1186/1471-2407-14-139.